Our ophthalmic study is a signature specialty of West China-Frontier PharmaTech. Our ophthalmologists collaborate
extensively with the ophthalmology department of the West China Hospital. Our lab has 4 well experienced study directors and 3 senior specialists who have conducted pre-clinic studies on ophthalmic medication or intraocular implantable biomaterials for over 10 years.
The lab has state-of-the-art instruments: Retinal camera and color photograph imaging system, fluorescein fundus
So far, the lab has conducted pre-clinic studies on 22 ophthalmic medications (macromolecular, small molecule or nucleic acid), of which 1 has come to market, 2 have obtained clinical approval, 9 have finished pre-clinical safety study and filed for clinical approval, 8 are under-going pre-clinical safety studies. Indications include age-related macular degeneration (AMD), uveitis and vitreum adhesion.
Laser-Induced Choroidal Neovascularization (CNV) Model in Rhesus Monkeys
Hyperbaric Oxygen-induced Fundus Neovascularization Model in Mice
Uveitis Model in Rabbit/Monkey
Vitreous Adhesion Model in Pig
Single- / Repeated-Dose Toxicity Study (with safety pharmacology, Immunotoxicity and Toxicokinetics) in Monkey/Rabbit
Rabbit Eye Irritation
Rabbit Intraocular Irrigation
Monkey/Rabbit Ocular Tissue Distribution Test
Drug Absorption Rate in Blood of Ocular Injection in Monkeys
Anterior Chamber Perfusion
Conjunctival Sac Dosing
Indirect Ophthalmoscopy: macula, optic nerve head, retina, and retinal vessels
Slit Lamp Examination: conjunctiva, cornea, anterior chamber, iris, lens etc.