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  • Home
  • About us
    • Company
    • CORE TEAM
    • QUALITY UNIT
    • BUSINESS
  • Services
    • GENERAL TOXICOLOGY
    • DART
    • GENETIC TOXICOLOGY
    • SAFETY PHARMACOLOGY
    • PK/TK
    • EFFICACY STUDY
    • OPHTHALMIC LAB
    • CARCINOGENES
    • Project Management System for Client
  • Laboratories
    • PATHOLOGY LAB
    • CLINICAL LAB
    • BIO-ANALYSIS
    • TEST ARTICLE LAB
  • Animal Welfare
    • Animal welfare
  • News&Events
  • Chinese
    • Ophthalmic Lab

      Our ophthalmic study is a signature specialty of West China-Frontier PharmaTech. Our ophthalmologists collaborate

      extensively with the ophthalmology department of the West China Hospital. Our lab has 4 well experienced study directors and 3 senior specialists who have conducted pre-clinic studies on ophthalmic medication or intraocular implantable biomaterials for over 10 years.

       

      The lab has state-of-the-art instruments: Retinal camera and color photograph imaging system, fluorescein fundus

      angiography, laser photocoagulator, electro-physiological diagnostic systems, optical coherence tomography (OCT),

      ophthalmotonometer etc.

       

      So far, the lab has conducted pre-clinic studies on 22 ophthalmic medications (macromolecular, small molecule or nucleic acid), of which 1 has come to market, 2 have obtained clinical approval, 9 have finished pre-clinical safety study and filed for clinical approval, 8 are under-going pre-clinical safety studies. Indications include age-related macular degeneration (AMD), uveitis and vitreum adhesion.

       

      SERVICES

      Efficacy Study

      • Laser-Induced Choroidal Neovascularization (CNV) Model in Rhesus Monkeys
      • Hyperbaric Oxygen-induced Fundus Neovascularization Model in Mice
      • Uveitis Model in Rabbit/Monkey
      • Vitreous Adhesion Model in Pig
      Safety Evaluation
      • Single- / Repeated-Dose Toxicity Study (with safety pharmacology, Immunotoxicity and Toxicokinetics) in Monkey/Rabbit
      • Rabbit Eye Irritation
      • Rabbit Intraocular Irrigation

      Pharmacokinetics

      • Monkey/Rabbit Ocular Tissue Distribution Test
      • Drug Absorption Rate in Blood of Ocular Injection in Monkeys
      CAPABILITY
      • Administration Routes
      • Intravitreal Injection
      • Anterior Chamber Perfusion
      • Conjunctival Sac Dosing
      • Subretinal Injection

      Ophthalmologic Examination

      • Indirect Ophthalmoscopy: macula, optic nerve head, retina, and retinal vessels
      • Slit Lamp Examination: conjunctiva, cornea, anterior chamber, iris, lens etc.
      • Anterior Segment and Fundus Color Photography
      • Intraocular Pressure Examination
      • SOptical Coherence Tomography
      • Fluorescein Fundus Angiography
      • Electroretinography
      • Ocular Histopathology

       

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