• Concentration-time profile study, tissue-distribution study, study of excretion (into urine/bile/feces),

identification of in vivo metabolite(s), bioavailability study, bioequivalence study,

skin pharmacokinetics study；

In vitro PK study of drugs：

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Caco-2 cell permeability and absorption study, plasma protein binding study,

plasma stability study, metabolic stability study (microsome/hepatocyte),

in vitro characterization of metabolites (microsome/hepatocyte), CYP enzyme phenotyping study, drug-drug interaction study;

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WestChina-Frontier has multiple in vivo drug concentration analytical testing platforms for biotech drugs and uses Watson LIMS system for biological sample management and data management; its capability to carry out analytical study and provide technical services for the development of macromolecular drugs (e.g., antibodies), gene therapy drugs and cell therapy products is up to international standard.

Analysis of chemical drugs

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WestChina-Frontier has constructed an innovative small molecular drug PK/TK testing platform featuring high-sensitivity and high-specificity based on MS/MS and deployed Watson LIMS for biological sample management and data management to acquire the ability to analyze the in vivo concentration of trace amount drugs (e.g., chemical drugs, small peptides and small nucleic acids) with high-throughput, high-precision, and impressive-automation and to provide technical services.