WestChina-Frontier

Special Treatment: Evaluation of Ophthalmic Drugs Inhalation Formulation Study of Radioactive Isotope Labeled Drugs Neuropsychic Drug Studies Pediatric Drug Studies

Safety Evaluation: Safety Pharmacology General Toxicity Genetic Toxicology Reproductive and Development Toxicology Studies Carcinogenicity Test Drug Dependence Test Immunogenicity and Immunotoxicity Studies

Pharmacodynamic Evaluation: Eye disorder models Respiratory disorder model Tumor models Metabolic disorder models Neuropathy models Immuno-inflammatory disorder model Cardiovascular disorder models Other animal models

PK/TK Studies: In vivo PK study of drugs Out vitro PK study of drugs Plasma protein binding study Caco-2 cell permeability and absorption study Drug-drug interaction study In vivo PK study of drugs

Safety Pharmacology

WestChina-Frontier's safety pharmacology team consists of China’s national certified veterinarian and toxicologists. All members of the team are skilled, experienced, and possess the education background in clinical veterinary medicine, pharmacology and clinical medicine.

General Toxicity

WestChina-Frontier has an experienced and professional technical team for general toxicology, which is capable of conducting all-round toxicology evaluation and general toxicology study of drugs in line with NMPA/FDA/OECD/ICH regulatory and technical requirements and GLP requirements.

Genetic Toxicology

Through various genetic toxicity tests, WestChina-Frontier’s experienced professional genetic toxicology study team has accumulated massive background data and positive maps from genetic toxicity tests, and has gained extensive practical experience. The genetic toxicology study team can provide rapid and reliable preclinical screening of new drugs for potential mutagenicity/teratogenicity, or a complete set of GLP-compliant tests in line with applicable NMPA/FDA/ICH/EPA/OECD guidelines in support of clients’ regulatory submission for their new drug application in countries/regions worldwide.

Reproductive and Development Toxicology Studies

WestChina-Frontier’s well-experienced reproductive toxicology study director and researcher team have accumulated massive background data and positive maps, launched and completed China’s first large-scale reproductive toxicology study in monkeys, proving that WestChina-Frontier is capable of conducting reproductive toxicology study in monkeys.

Carcinogenicity Test

WestChina-Frontier is a pioneer in China in real-time acquisition, tracking, and analysis of tumor data in living animals using the carcinogenicity study module of a computerized system (Pristima v7.0, mass tracking module) to ensure the accuracy, scientificity and standardization of study data. We have completed more than ten two-year long-term carcinogenicity studies (in rats) and short-term carcinogenicity studies in transgenic mice, accumulating abundant background data and practical experience.

Drug Dependence Test

WestChina-Frontier is one of the earliest qualified Chinese platforms for GLP-compliant non-clinical study of drug dependence，With the professional researcher team for its solid theoretical basis and abundant experience, we can provide relevant consultation services, designing reasonable study protocols in light of study drug's characteristics and client's needs and carrying out them. The researcher team has established a number of test techniques for evaluation of the potential physical and psychological dependence of a drug and for pharmacodynamic research. So far, the team has conducted numerous non-clinical studies of drug dependence in line with NMPA/OECD/FDA regulatory requirements.

Immunogenicity and Immunotoxicity Studies

WestChina-Frontier has established the immunogenicity and immunotoxicity study system to provide the biopharmaceutical industry with all-round testing service covering the entire pre-clinical development cycle of new drugs. The system is dedicated to the development and evaluation of cell therapy, gene therapy and other high-end biological therapy products.

Business Contacts：028-60662528

E-mail：service@glpcd.com

+8628-60662518-8800

+8628-85154334-800

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